2020): root mean square deviation (RMSD) ( Kabsch 1978) deformation index (DI) that normalizes RMSD with the sequence length ( Parisien et al. Similarity and distance measures ( Magnus et al. It provides accuracy assessments determined in comparison with the reference structure and calculation of several global As of October 2020, 22 challenges have been concluded with assessment results available on the RNA-Puzzles website ( ). The basis of four scientific papers published by the RNA-Puzzles community ( Cruz et al. Presently, 28 crystallographic structures have been part of the contest. After the deadline, the predictions are evaluated and the results are published with the ranking The web servers have 48 h and human experts 3–4 RNA 3D structure, the conformation of which is unknown to the predictors. The starting point for each challenge is a novel experimentally determined Or human experts running various prediction programs. Of challenges, depending on the protocols used to obtain the models: They can originate from fully automated web services Assessment against the experimental structure is performed after the release of the structure. Before the publication of an experimentallyĭetermined RNA structure, the sequence is disseminated among the community and prediction results are submitted within 3–4 RNA 3D structure prediction to promote the improvement of prediction methods. RNA-Puzzles is a community-wide assessment of RNA 3D structure prediction that aims to understand the bottlenecks in current To stimulate the improvement of quality in RNA prediction, RNA-Puzzles was organized 10 yr ago ( Cruz et al. In the following years, this collection grew to include other tools such as ModeRNA ( Rother et al. Some of them developed into highly specialized programs, which are used for either fully automatic or human-guided prediction. 2008), MC-Fold/MC-Sym ( Parisien and Major 2008), and NAST ( Jonikas et al. Modeling of RNA 3D structures: S2S ( Jossinet and Westhof 2005), FARFAR ( Das and Baker 2007), iFoldRNA ( Ding et al. The first decade of the 21st century resulted in several computer programs and protocols, which paved the way for automated Of RNA three-dimensional models from the sequence have been developed to help or bypass some hurdles of laboratory procedures
Knowledge of the RNA atomic structure is crucial to address biological problems, therefore computational tools for the prediction Previous Section Next Section INTRODUCTION
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